Avail Biomedical Research Institute

Scientific Excellence and Innovation in Pulmonary Biomedical Research


Selected Publications

Mattoli S, Schmidt M. Investigational use of mesenchymal stem/stromal cells and their secretome as add-on therapy in severe respiratory virus infections: Challenges and perspectives. Adv Ther 2023; 40(6): 2626-92. Epub 2023 Apr 17. https://doi.org/10.1007/s12325-023-02507-z.

Mattoli S. Pathogenetic and prognostic role of bloodborne fibrocytes in asthma. Invited Review. J Zhejinang Univ Sci B 2015; 16(8): 651-660. http://dx.doi.org/10.1631/Jzus.B1500129.  

Barczyk M, Schmidt M, Mattoli S. Stem cell-based therapy in idiopathic pulmonary fibrosis. Stem Cell Rev Rep 2015; 11(4):598-620. http://dx.doi.org/10.1007/s12015-015-9587-7. 

Mattoli S. Involvement of fibrocytes in asthma and clinical implications. Invited Review. Clin Exp Allergy 2015; 45: 1497-1509. http://dx.doi.org/10.1111/cea.12525. 

Bianchetti L, Isgrò M, Marini MA, Bellini A, Schmidt M, Mattoli S. Enumeration of circulating fibrocytes for clinical use in asthma by an optimized single-platform flow cytometry assay. BBA Clinical 2014; 1: 52-58. http://dx.doi.org/10.1016/j.bbacli.2014.06.002. 

Schmidt M, Mattoli S. A mouse model for evaluating the contribution of fibrocytes and myofibroblasts to airway remodeling in allergic asthma. Methods Mol Biol 2013; 1032: 235-255. http://dx.doi.org/10.1007/978-1-62703-496-8_19. 

Isgrò M, Bianchetti L, Marini MA, Mattoli S. Involvement of fibrocytes in allergen-induced T cell responses and rhinovirus infections in asthma. Biochem Biophys Res Commun 2013; 437(3): 446-451. http://dx.doi.org/10.1016/j.bbrc.2013.06.099.   

Bellini A, Schmidt M, Mattoli S. Interactions between the bronchial epithelium and fibrocytes in the pathogenesis of airway remodeling in asthma. Journal of Epithelial Biology and Pharmacology 2013; 6: 1-10. http://dx.doi.org/10.2174/1875044301306010001. 

Isgrò M, Bianchetti L, Marini MA, Bellini A, Schmidt M, Mattoli S. The C-C motif chemokine ligands CCL5, CCL11, and CCL24 induce the migration of circulating fibrocytes from patients with severe asthma. Mucosal Immunol 2013; 6(4): 718-727. http://dx.doi.org/10.1038/mi.2012.109.

Bianchetti L, Marini MA, Isgrò M, Bellini A, Schmidt M, Mattoli S. IL-33 promotes the migration and proliferation of circulating fibrocytes from patients with allergen-exacerbated asthma. Biochem Biophys Res Commun 2012; 426(1): 116-21. http://dx.doi.org/10.1016/j.bbrc.2012.08.047.

Mattoli S, Barczyk M, Bellini A. Fibrocytes in Asthma. In: Fibrocytes in Health and Disease. Chapter 7. Bucala R, Ed. Singapore: World Scientific Publishing. 2012: 113-30. 

Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S. Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol 2012; 5(2): 140-9. http://dx.doi.org/10.1038/mi.2011.60.

Bianchetti L, Barczyk M, Cardoso J, Schmidt M, Bellini A, Mattoli S. Extracellular matrix remodelling properties of human fibrocytes. J Cell Mol Med. 2012; 16(3): 483-95. http://dx.doi.org/10.1111/j.1582-4934.2011.01344.x.

Bellini A, Mattoli S. Fibrocytes (Reactive or Reparative). In: Cell Therapy for Lung Disease. Chapter 8. Polak J, Ed. London: Imperial College Press. 2010: 237-52. 

Mattoli S, Bellini A, Schmidt M. The role of a human hematopoietic mesenchymal progenitor in wound healing and fibrotic diseases and implications for therapy. Curr Stem Cell Res Ther 2009; 4(4): 266-80. Review. http://dx.doi.org/10.2174/157488809789649232.

Schmidt M, Mattoli S. Role in asthmatic lung disease. In: Fibrocytes: New Insights into Tissue Repair and Systemic Fibroses. Chapter 6. Bucala R, Ed. Singapore: World Scientific Publishing. 2007: 105-23. 

Bellini A, Mattoli S. The role of the fibrocyte, a bone marrow-derived mesenchymal progenitor, in reactive and reparative fibroses. Lab Invest 2007; 87(9): 858-70. Review. http://doi.org/10.1038/labinvest.3700654.

Mattoli S. Tissue repair in asthma: The origin of subepithelial fibroblasts and myofibroblasts. In: Tissue Repair, Contraction and the Myofibroblasts. Chapter 4. Chaponnier C, Desmoulière A, Gabbiani G, Eds. Georgetown (TX): Landes Bioscience and Springer Science + Business Media. 2006: 40-6. 

Mori L, Bellini A, Stacey MA, Schmidt M, Mattoli S. Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. Exp Cell Res 2005; 304(1): 81-90. http://doi.org/10.1016/j.yexcr.2004.11.011.  

Schmidt M, Sun G, Stacey MA, Mori L, Mattoli S. Identification of circulating fibrocytes as precursors of bronchial myofibroblasts in asthma. J Immunol 2003; 171(1): 380-9. http://doi.org/10.4049/jimmunol.171.1.380.  

Mattoli S. Allergen-induced generation of mediators in the mucosa. Environ Health Perspect 2001; 109 Suppl 4: 553-7. Review. http://doi.org/10.1289/ehp.01109s4553.

Sun G, Stacey MA, Schmidt M, Mori L, Mattoli S. Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J Immunol 2001; 167(2): 1014-21. http://doi.org/10.4049/jimmunol.167.2.1014.

Brown JR, Kleimberg J, Marini M, Sun G, Bellini A, Mattoli S. Kinetics of eotaxin expression and its relationship to eosinophil accumulation and activation in bronchial biopsies and bronchoalveolar lavage (BAL) of asthmatic patients after allergen inhalation. Clin Exp Immunol 1998; 114(2): 137-46. http://doi.org/10.1046/j.1365-2249.1998.00688.x.

Sun G, Stacey MA, Vittori E, Marini M, Bellini A, Kleimberg J, Mattoli S. Cellular and molecular characteristics of inflammation in chronic bronchitis. Eur J Clin Invest 1998; 28(5): 364-72. http://doi.org/10.1046/j.1365-2362.1998.00285.x.  

Mattoli S, Kleimberg J, Stacey MA, Bellini A, Sun G, Marini M. The role of CD8+ Th2 lymphocytes in the development of smoking-related lung damage. Biochem Biophys Res Commun 1997; 239(1): 146-9. http://doi.org/10.1006/bbrc.1997.7444.  

Stacey MA, Sun G, Vassalli G, Marini M, Bellini A, Mattoli S. The allergen Der p1 induces NF-kappaB activation through interference with IkappaB alpha function in asthmatic bronchial epithelial cells. Biochem Biophys Res Commun 1997; 236(2): 522-6. http://doi.org/10.1006/bbrc.1997.6997.  

Mattoli S, Stacey MA, Sun G, Bellini A, Marini M. Eotaxin expression and eosinophilic inflammation in asthma. Biochem Biophys Res Commun 1997; 236(2): 299-301. http://doi.org/10.1006/bbrc.1997.6958.

Sun G, Stacey MA, Bellini A, Marini M, Mattoli S. Endothelin-1 induces bronchial myofibroblast differentiation. Peptides. 1997; 18(9): 1449-51. http://doi.org/10.1016/s0196-9781(97)00194-0.




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